Why the study?
Does Jian-Pi-Zhi-Dong Decoction improve stereotypic behaviors and regulate GABA expression in a mouse model of Tourette syndrome?
Does Jian-Pi-Zhi-Dong Decoction improve stereotypic behaviors and regulate GABA expression in a mouse model of Tourette syndrome?
Jian-Pi-Zhi-Dong Decoction alleviates Tourette syndrome symptoms in a mouse model, potentially by downregulating GABAAR expression in the striatum.
Supports JPZDD investigation in TS models; leaves open translation to human therapy.
The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD) on Tourette syndrome (TS) by investigating the expression of gamma-aminobutyric acid (GABA) and its type A receptor (GABAAR) in the striatum of a TS mice model. The model was induced by 3,3'-iminodipropionitrile (IDPN) treatment; then mice were divided into 4 groups (n=22, each); control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism.
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Zhang et al. (2014) studied this question.
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