This report of two cases highlights the clinical presentation, management, and genetic basis (ryanodine receptor type 1 gene mutations) of malignant hyperthermia during general anesthesia.
Supports targeted RYR1 testing after malignant hyperthermia; leaves open broader screening utility pending larger studies.
Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality. We present two seemingly typical cases of intraoperative MH development, with details on perioperative assessment and rescue. Postoperative genetic test showed mutations in the ryanodine receptor type 1 gene.
No takes yet. Share an insight, caveat, or question.
Chi et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: