Why the study?
Skin lesions in hand, foot, and mouth disease rarely become necrotic, but represent a severe complication requiring hospitalization when present.
Intravenous acyclovir combined with supportive care may be an effective treatment for severe necrotic mucocutaneous lesions complicating hand, foot, and mouth disease.
In most cases, the cause of hand, foot, and mouth disease (HFMD) is coxsackievirus A type 16. The infection can also be caused by other strains of coxsackievirus, spreading mainly by the oral-fecal route, while it is less likely to be transmitted through secretions. HFMD occurs mainly in summer and is more common in children under ten. Skin lesions develop during the disease but rarely become necrotic. When present, they are a severe complication requiring hospitalization. This paper reports the case of a patient with HFMD who developed necrotic mucocutaneous lesions that responded favorably to intravenous acyclovir, fluids, and electrolyte support therapy.
No takes yet. Share an insight, caveat, or question.
Velástegui et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: