Key result
MicroRNAs play a significant role in enteroviral infections by modulating viral pathogenesis and replication through the regulation of viral or host gene expression.
This review highlights the bidirectional interaction between enteroviral infections and cellular microRNAs, which may have implications for understanding viral pathogenesis including viral myocarditis.
Answers are grounded in this paper and cite their sources.
May inform enteroviral myocarditis mechanisms; leaves open microRNA-targeted therapies pending interventional trials.
The genus Enterovirus, a member of the Picornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection of Enterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.
No takes yet. Share an insight, caveat, or question.
Wu et al. (2015) conducted a review in Enteroviral infections. MicroRNAs was evaluated. MicroRNAs play a significant role in enteroviral infections by modulating viral pathogenesis and replication through the regulation of viral or host gene expression.
Synapse has enriched 10 related papers. Consider them for comparative context: