Key result
Plasma levels of superoxide dismutases 1 and 2 were elevated in patients with coronary artery disease compared to healthy controls, whereas SOD3 levels showed no difference.
Why the study?
Are plasma levels of superoxide dismutases 1, 2, and 3 elevated in patients with coronary artery disease compared to controls?
Case-Control (n=124)
Are plasma levels of superoxide dismutases 1, 2, and 3 elevated in patients with coronary artery disease compared to controls?
Plasma levels of SOD1 and SOD2 are elevated in patients with coronary artery disease and may serve as potential surrogate biomarkers.
Answers are grounded in this paper and cite their sources.
Elevated SOD1/SOD2 may reflect CAD oxidative stress; hypothesis-generating for biomarkers and leaves clinical utility open.
Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD).Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n=33 ), patients with acute coronary syndrome (ACS, n=49 ), and controls ( n=42 ). Protein quantification was done using ELISA.Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis.Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.
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Peng et al. (2016) conducted a case-control in Coronary Artery Disease (n=124). Plasma superoxide dismutases (SOD1, SOD2, SOD3) levels vs. Healthy controls was evaluated on Plasma levels of SOD1, SOD2, and SOD3. Plasma levels of superoxide dismutases 1 and 2 were elevated in patients with coronary artery disease compared to healthy controls, whereas SOD3 levels showed no difference.
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