Key result
The 4q25 genetic variant rs2200733 was associated with a increased risk of atrial fibrillation, while rs6838973 was associated with a reduced risk.
Why the study?
Variants at locus 4q25 are associated with atrial fibrillation development and left atrial volume predicts recurrence, but their association with echocardiographic parameters remained to be clarified.
Are 4q25 genetic variants associated with the risk of atrial fibrillation and altered echocardiographic parameters?
Case-Control (n=360)
Yes
Are 4q25 genetic variants associated with the risk of atrial fibrillation and altered echocardiographic parameters?
Answers are grounded in this paper and cite their sources.
Specific genetic variants at the 4q25 locus are associated with the risk of atrial fibrillation, age of onset, and left atrial volume index, highlighting a genetic component to atrial structural remodeling.
Atrial fibrillation (AF), the most common type of arrhythmia, has a heritable component. Variants at locus 4q25 are best associated with the risk of AF development in genome-wide association studies. Left atrial volume is an independent predictor of recurrence of AF after successful sinus rhythm restoration. The aim of our study was to investigate potential association between genetic variants at 4q25 locus and the risk of AF and echocardiographic parameters. We included 241 AF patients and 119 control individuals into the study. Left ventricle ejection fraction (LVEF, %) and left atrial volume index (LAVI, ml/m 2 ) were assessed by transthoracic echocardiography during outpatient visits. We selected five 4q25 genetic variants (rs6825911, rs1126483, rs10004516, rs6838973, rs2200733) for the analysis. Variant rs6838973 was found to be associated with reduced risk of AF in additive (CCTT) and dominant (CC vs. CT+TT) models of inheritance. On the other hand, additive (CC 2 (IQR = 10.0) and median LVEF was 56.0% (IQR = 13.0). Statistically significant association was observed only between LAVI and variant rs1126483 in the dominant model of inheritance (median LAVI in CC vs. CT+TT – 38 ml/m 2 vs. 40 ml/m 2 , U = 1602.5, p = 0.032). No significant association was found for LVEF and the analysed genotypes.
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Rudaka et al. (2020) conducted a case-control in Atrial fibrillation (n=360). 4q25 genetic variants (rs2200733 and rs6838973) vs. Wild-type/other genotypes was evaluated on Risk of atrial fibrillation (rs2200733 dominant model) (OR 1.961, 95% CI 1.227-3.133, p=0.005). The 4q25 genetic variant rs2200733 was associated with a increased risk of atrial fibrillation, while rs6838973 was associated with a reduced risk.
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