Key result
Zero fluoroscopy PVC ablation successfully treated high-burden PVC in 6 pregnant women, allowing all to deliver term infants without the use of beta-blockers.
Why the study?
Managing symptomatic high-burden PVC in pregnancy is challenging because of potential maternal and fetal adverse outcomes, risks of beta blockers, and underrepresentation in clinical trials.
Does zero fluoroscopy PVC ablation safely and effectively treat symptomatic high-burden PVCs in pregnant patients?
Case Report (n=6)
No
Does zero fluoroscopy PVC ablation safely and effectively treat symptomatic high-burden PVCs in pregnant patients?
Zero fluoroscopy PVC ablation using 3D electroanatomical mapping is a feasible and safe strategy for managing high-burden symptomatic PVCs during pregnancy, avoiding potential fetal harm from medications or radiation.
May offer beta-blocker alternative for symptomatic PVCs in pregnancy; leaves open need for prospective safety data.
Premature ventricular complex (PVC) constitutes the most prevalent arrhythmia in pregnancy. Because of the potentially adverse maternal and fetal outcomes, managing symptomatic high-burden PVC in pregnancy is challenging; thus, selecting the optimal treatment is crucial. Conventionally, PVC has been managed with beta blockers. However, beta blockers may have negative consequences on the developing fetus. PVC ablation can be performed in patients without fluoroscopy using three-dimensional electroanatomical technology. We present a clinical case series of 6 high-burden pregnant patients who underwent single catheter PVC ablation with zero fluoroscopy during the second trimester of pregnancy. The right ventricular outflow tract was the site of origin of the PVC, which was effectively ablated. All patients were able to continue the pregnancy and delivered at full term. Managing pregnant patients with high-burden PVC is challenging as this population is underrepresented in clinical trials. This case series details the successful management of PVC in pregnancy.
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Krishinan et al. (2025) conducted a case report in Symptomatic high-burden premature ventricular complex (PVC) in pregnancy (n=6). Zero fluoroscopy PVC ablation was evaluated on Ability to deliver a term infant without using a beta-blocker. Zero fluoroscopy PVC ablation successfully treated high-burden PVC in 6 pregnant women, allowing all to deliver term infants without the use of beta-blockers.
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