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Matchmaker, matchmaker: A gold-nanoparticle-based light-scattering assay has been developed for sensitive detection of DNA hybridization. The assay relies on the enhancement of light scattering that originates from the aggregation of oligonucleotide-functionalized gold nanoparticles directed by the target DNA. The assay also exhibits a high degree of discrimination between perfectly matched target DNA and targets with single base-pair mismatches.
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Du et al. (2006) studied this question.
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