June 1, 1995Journal of Clinical InvestigationOpen Access

Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat.

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Population

Young female Sprague-Dawley rats

Comparison

Ablumenal application of Endothelin-1, 2, or 3… vs Baseline vessel diameter in the absence of…

Design

Preclinical

Follow-up

up to 40 minutes (in vitro)

Authors

ESErik P. SilldorffTowson University SYShiming YangChinese PLA General Hospital TPThomas L. PalloneUniversity of Maryland, Baltimore

Discussion

Member takes

Implication

Endothelin-PGE2 interactions may regulate medullary perfusion in animal models; leaves open relevance to human renal hemodynamics.

Structured PICO

Population

Young female Sprague-Dawley rats (in vitro microperfused outer medullary descending vasa recta dissected from vascular bundles)

Intervention

Ablumenal application of Endothelin-1, 2, or 3, with or without ETA/ETB receptor antagonists (BQ-123, BQ-610, BQ-788, IRL-1038, RES-701-1) and Prostaglandin E2 (PGE2)

Comparator

Baseline vessel diameter in the absence of hormones, or vehicle control

Outcome

Percent constriction of vessel inner diametersurrogate

Endothelins are highly potent constrictors of renal outer medullary descending vasa recta, an effect that is modulated by prostaglandin E2, suggesting interactive local hormonal control of medullary perfusion.

Limitations

In vitro perfused OMDVR provides only a system for bioassay of concentration dependent hormonal effects on vasoconstriction, and the intense vasoconstriction observed in vitro might not exist in vivo.

Cite This Study

Silldorff et al. (1995) studied this question.

synapsesocial.com/papers/6a8c0cbfde5ec4e001e3e4ea https://doi.org/10.1172/jci117976

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Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider