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R factors conferring high-level resistance to trimethoprim and sulphonamides were identified in bacteria causing infections in patients at three London hospitals in 1971 (Fleming, Datta & Grüneberg, 1972). All were members of the W compatability group and came from the Camden area (Datta & Hedges, 1972).
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Hedges et al. (1972) studied this question.
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