Key result
Thoracic aortic calcification failed to improve prediction of coronary events (HR 0.98; 95% CI 0.91-1.05; p=0.56) and all-cause mortality over coronary artery calcification.
Why the study?
Does thoracic aortic calcification (TAC) improve the prediction of incident myocardial infarction and all-cause mortality over coronary artery calcification (CAC) in subjects without known coronary artery disease?
Population
4,040 participants without known coronary artery disease from the population-based prospective Heinz Nixdorf…
Comparison
Thoracic aortic calcification score quantified… vs Coronary artery calcification score and…
Design
Cohort
Follow-up
mean 8.0 ± 1.5 years
Authors
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TAC adds no incremental value to CAC for event prediction; hypothesis-generating for refined imaging markers in primary prevention.
Cohort (n=4,040)
Does thoracic aortic calcification (TAC) improve the prediction of incident myocardial infarction and all-cause mortality over coronary artery calcification (CAC) in subjects without known coronary artery disease?
Hazard Ratio: 0.98 (95% CI 0.91–1.05)
p-value: p=0.56
While thoracic aortic calcification is associated with incident coronary events and mortality, it does not improve risk prediction over coronary artery calcification in the general population.
Kälsch et al. (2013) conducted a cohort in without known coronary artery disease (n=4,040). Thoracic aortic calcification (TAC) vs. TAC = 0 or lower TAC burden was evaluated on coronary events (after adjustment for CAC-score) (HR 0.98, 95% CI 0.91-1.05, p=0.56). Thoracic aortic calcification failed to improve prediction of coronary events (HR 0.98; 95% CI 0.91-1.05; p=0.56) and all-cause mortality over coronary artery calcification.
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