April 30, 1996Proceedings of the National Academy of SciencesOpen Access

Foamy virus reverse transcriptase is expressed independently from the Gag protein.

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Population

Preclinical model using cell lines transfected with infectious human foamy virus plasmid pHSRV2 and its…

Comparison

Genetic mutations in the pol ATG codon and… vs Wild-type infectious HFV plasmid pHSRV2

Design

Preclinical

Authors

JEJörg EnssleUniversity of Potsdam IJIngo JordanUniversity of California, Irvine BMB MauerUniversity of Würzburg

Discussion

Member takes

Implication

Challenges retroviral Gag-Pol fusion paradigm in foamy viruses; leaves open relevance to human infections or antivirals.

Structured PICO

Population

Preclinical model using cell lines (BHK-21, 3T3 TK-, U251-MG, BHK/LTRlacZ) transfected with infectious human foamy virus (HFV) plasmid pHSRV2 and its mutants.

Intervention

Genetic mutations in the pol ATG codon and gag-pol overlap region (M53, M54, M55, M56, M57)

Comparator

Wild-type infectious HFV plasmid pHSRV2

Outcome

Virus replication competence and expression of Gag and Pol proteins

Foamy viruses differ fundamentally from other retroviruses by expressing their reverse transcriptase (Pol) independently from the Gag protein, rather than as a Gag-Pol fusion protein.

Cite This Study

Enssle et al. (1996) studied this question.

synapsesocial.com/papers/6a8c0f04f8241cb45bfb7e4c https://doi.org/10.1073/pnas.93.9.4137

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Foamy virus reverse transcriptase is expressed independently from the Gag protein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Foamy virus reverse transcriptase is expressed independently from the Gag protein.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider