This review summarizes the causes, consequences, and prognostic significance of neuroendocrine activation following myocardial infarction.
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May inform post-MI risk stratification; leaves open whether modulating neuroendocrine activation improves outcomes.
Increases in plasma concentrations of a num- ber of neuroendocrine substances are well documented after myocardial infarction. The objectives of this paper are to describe the time course of neuroendocrine activation after myocardial infarction, the evidence for activa- tion of the cardiac renin-angiotensin system, possible causes and consequences of neuroen- docrine activation, the influence of patient genotype on outcome, and the ability of early neuroendocrine activation to predict progno- SiS.
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Cleland et al. (1996) studied this question.
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