Population
60 patients with acute myocardial infarction within 6 hours of pain, including those developing heart…
Design
Cohort
Follow-up
10 days
Authors
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Elevated day-3 angiotensin II associated with post-MI HF; hypothesis-generating for early ACE-inhibitor timing trials.
Neuroendocrine activation, specifically elevated angiotensin II, occurs early in acute myocardial infarction and is more pronounced in patients developing heart failure, suggesting a pathophysiological basis for early ACE inhibitor use.
Dargie et al. (1987) studied this question.
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