Initial peak concentrations of noradrenaline correlated negatively with left ventricular ejection fraction at discharge (r = –0.72, p < 0.05) in patients with acute myocardial infarction.
Do early adrenaline and noradrenaline levels predict left ventricular ejection fraction in patients with acute myocardial infarction?
Early catecholaminergic activation in acute myocardial infarction is restricted to the first 5 days, and its magnitude inversely correlates with left ventricular systolic performance.
Absolute Event Rate: 0% vs 0%
Aim: The study was designed to assess (1) the time course of catecholaminergic activation in acute myocardial infarction (AMI) as estimated by adrenaline (ADR) and noradrenaline (NOR) concentrations, and (2) to relate activation of these hormones to predict the outcome of cardiac performance. Patients and Methods: Eighteen patients with first AMI were studied. Blood samples were drawn within the first 4–18 h, after 18–24 h, on day 2, day 3 and on day 6 as well as after 1 year. Radionuclide ventriculography was performed on the day of discharge and after 1 year to determine left-ventricular ejection fraction (LVEF). Results: In the study group as a whole, the concentrations of ADR decreased from (mean ± SEM) 0.80 ± 0.12 nmol/l on admission to 0.33 ± 0.03 nmol/l at discharge (p 0.50 (p Conclusion: (1) Catecholaminergic activation, as measured by plasma ADR and NOR in AMI, is acute and restricted to the first 5 days. Thereafter, the hormone levels are normal and stable. (2) The magnitude of the early catecholaminergic activation correlates with left ventricular systolic performance. (3) Normal NOR values at admittance predicts normal or almost normal LVEF at discharge.
Petersen et al. (Wed,) reported a other. Initial peak concentrations of noradrenaline correlated negatively with left ventricular ejection fraction at discharge (r = –0.72, p < 0.05) in patients with acute myocardial infarction.