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August 1, 1974Journal of Clinical InvestigationOpen Access

Plasma Catecholamines and Carbohydrate Metabolism in Patients with Acute Myocardial Infarction

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Why the study?

Do elevated plasma catecholamines correlate with altered carbohydrate metabolism in patients with acute myocardial infarction?

Population

10 patients with acute myocardial infarction admitted within 12 hours after onset of precordial pain, and 5…

Comparison

Measurement of plasma catecholamines and… vs Healthy control subjects without evidence of…

Design

Cohort

Follow-up

3 months (for a subset of 4 patients)

Authors

NCNiels Juel ChristensenUniversity of Wisconsin–MadisonJVJørgen VidebækCopenhagen University Hospital

Discussion

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Implication

Elevated noradrenaline associates with glucose intolerance in AMI; hypothesis-generating for adrenergic effects on metabolism, needing prospective confirmation.

Structured PICO

Do elevated plasma catecholamines correlate with altered carbohydrate metabolism in patients with acute myocardial infarction?

P
Population
10 patients with acute myocardial infarction (AMI) admitted within 12 hours after onset of precordial pain, and 5 healthy control subjects. Mean age 61 in AMI group, 70% male.
I
Intervention
Measurement of plasma catecholamines (noradrenaline, adrenaline) and carbohydrate metabolism parameters, including an intravenous glucose tolerance test (25 g glucose over 4 min).
C
Comparator
Healthy control subjects without evidence of cardiovascular disease.
O
Outcome
Correlation between plasma catecholamines (noradrenaline, adrenaline) and metabolic parameters (fasting blood glucose, serum insulin, free fatty acids, and glucose tolerance K value).surrogate

In patients with acute myocardial infarction, elevated plasma noradrenaline levels strongly correlate with fasting hyperglycemia and impaired glucose tolerance, suggesting that augmented adrenergic activity directly drives early metabolic alterations in AMI.

Limitations

  • Small sample size
  • Only 4 of the 10 patients were available for re-examination at 3 months

Cite This Study

Christensen et al. (1974) studied this question.

synapsesocial.com/papers/6a74f47ff2cd31a1fadbefefhttps://doi.org/10.1172/jci107763
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intravenous glucose tolerance, insulin, glucose, and free fatty acid levels after myocardial infarction1969 · 95 citations
  2. 2Acute Metabolic Responses to Myocardial Infarction1969 · 51 citations
  3. 3Intravenous glucose tolerance in myocardial infarction1971 · 9 citations
  4. 4PLASMA‐HYDROCORTISONE VALUES IN HEART DISEASE1969 · 10 citations
  5. 5Titration of free fatty acids of plasma: a study of current methods and a new modification1960 · 1,022 citations