Key result
Uncomplicated acute myocardial infarction was associated with protracted sympathetic hyperactivity at 6 months compared to normal subjects (MSNA 75 vs 51 bursts/100 beats; P<0.01).
Why the study?
Does sympathetic neural hyperactivity persist over time after uncomplicated acute myocardial infarction compared to controls?
Population
13 patients with uncomplicated acute myocardial infarction, and 3 matched control groups
Comparison
Assessment of muscle sympathetic nerve activity… vs Normal subjects, patients with coronary artery…
Design
Cohort
Follow-up
6 months
Authors
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Sympathetic hyperactivity may persist after uncomplicated AMI; leaves open causal links to outcomes and need for intervention trials.
Observational
Does sympathetic neural hyperactivity persist over time after uncomplicated acute myocardial infarction compared to controls?
Absolute Event Rate: 75% vs 51%
p-value: p=<0.01
Sympathetic neural hyperactivity persists for at least 6 months after uncomplicated acute myocardial infarction, which may contribute to delayed cardiovascular morbidity.
Graham et al. (2002) conducted an observational in Uncomplicated acute myocardial infarction. Uncomplicated acute myocardial infarction vs. Normal subjects, patients with coronary artery disease, and hospitalized patients without AMI was evaluated on Muscle sympathetic nerve activity (MSNA) at 6 months (p=<0.01). Uncomplicated acute myocardial infarction was associated with protracted sympathetic hyperactivity at 6 months compared to normal subjects (MSNA 75 vs 51 bursts/100 beats; P<0.01).
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