Answers are grounded in this paper and cite their sources.
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus.
No takes yet. Share an insight, caveat, or question.
Emini et al. (1990) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: