Multiple Myeloma Associated with Two Serum M Components, γG Type K and γA Type L

ON paper electrophoresis, the serum proteins of many patients with multiple myeloma are characterized by a single M component consisting of globulin molecules of uniform electrophoretic mobility. M components in this disease may be assigned to either the γG or γA, or rarely the γD1 class of human immunoglobulins on the basis of physicochemieal and antigenic properties of their heavy chains, designated γ, α and δ, respectively.1 , 2 Unlike normal gamma globulins which consist of a mixture of molecules having either kappa (60 per cent) or lambda (30 per cent) light chains,3 M component molecules uniformly possess either one or the . . .