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A cardinal physiologic principle is that body cells function best when the blood and interstitial fluid around them and the intracellular fluid within them stay relatively constant in volume and composition. Homeostasis, or fluid balance, is the term which indicates normal relative constancy of body fluids. Fluid imbalance, therefore, implies some deviation from normal volume or composition of extracellular and intracellular fluids.
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Catherine P. Anthony (1963) studied this question.
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