Bilateral Acute Angle-closure Glaucoma Associated With Drug Sensitivity to Hydrochlorothiazide

Numerous pharmacological agents, including the sulfonamides, have been reported to cause acute transient myopia.1Rarely, such episodes can be associated with the concurrent development of acute angle-closure glaucoma (ACG).2We report a case of bilateral anterior choroidal effusions and acute ACG secondary to the ingestion of 25 mg of hydrochlorothiazide. Report of a Case. A 53-year-old man with a history of hypertension was seen by his local ophthalmologist with the complaint of progressive blurring of his vision that was associated with a severe bifrontal headache and ocular pain during the previous 24 hours. Forty-eight hours earlier he had ingested one 25-mg tablet of hydrochlorothiazide, a medication that he had used approximately 5 years previously without difficulty. He was taking no ocular medications and had been treated long term with enalopril maleate (Vasotec). Two hours later, a non-productive cough developed with mild shortness of breath. A chest x-ray film