The study demonstrates that myosin heads do not move from their resting positions upon activation in the absence of actin.
Indicates actin interaction is required for myosin head movement; leaves open applicability to intact cardiac sarcomeres in vivo.
Highly stretched muscles in which thick and thin filaments no longer overlap produce little or no tension on activation. In preparations producing no tension, the 42.9-nanometer myosin layer line shown in x-ray diffraction patterns does not become weaker. This suggests that myosin heads do not move from their resting positions in the absence of actin.
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Yagi et al. (1980) studied this question.
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