February 1, 1974Proceedings of the National Academy of SciencesOpen Access

The Site of Force Generation in Muscle Contraction as Deduced from Fluorescence Polarization Studies

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Population

Rabbit glycerinated psoas muscle fibers

Design

Preclinical

Authors

TNT. NiheiKyoto University RMRobert A. MendelsonMonsanto (United States)JBJean BottsNaval Medical Research Command

Discussion

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Implication

Supports Huxley-Simmons model in rabbit fibers; leaves open translation to human cardiac mechanics.

Structured PICO

Population

Rabbit glycerinated psoas muscle fibers

Intervention

Fluorescence polarization using N(-iodoacetylamino)-l-naphthylanine-5-sulfonic acid dye under various conditions (rigor-inducing, relaxation-inducing, contraction-inducing solutions, and alpha,beta-methylene ATP)

Outcome

Cross-bridge orientation as a function of sarcomere lengthsurrogate

Fluorescence polarization studies in rabbit muscle fibers provide mechanistic evidence that torque during muscle contraction is generated at the actin-myosin interface.

Cite This Study

Nihei et al. (1974) studied this question.

synapsesocial.com/papers/6a8bca0490fae8fd47e9934c https://doi.org/10.1073/pnas.71.2.274

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The Site of Force Generation in Muscle Contraction as Deduced from Fluorescence Polarization Studies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Site of Force Generation in Muscle Contraction as Deduced from Fluorescence Polarization Studies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider