Individual States in the Cycle of Muscle Contraction

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Population

Isometrically-held glycerol-extracted psoas fibers from rabbits

Design

Preclinical

Authors

Discussion

Does not inform clinical cardiac care; leaves open validation of myosin state transitions in human myocardium.

Population

Isometrically-held glycerol-extracted psoas fibers from rabbits

Intervention

Analogs of ATP to force fibers into states corresponding to molecular species in the contractile cycle

Outcome

Measurement of P[unk], a fluorescence polarization parameter relating to the attitude of S-1 moieties of myosin moleculessurrogate

The study proposes a sequence of states in the muscle contraction cycle based on fluorescence polarization measurements of myosin S-1 moieties.

Remedios et al. (1972) studied this question.

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