A mouse/rabbit hybrid clone producing a rabbit immunoglobulin x light chain of allotype b4 is described. After one year in culture the clone is still producing the rabbit x chain and carries all the chromosomes of the mouse parental cell and one rabbit chromosome, No. 15. On two occasions, one month apart, this chromosome was present in 80% and 100% of the mitoses. Three hybrid lines not producing rabbit immunoglobulin chains did not carry any rabbit chromosomes.
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Suomalainen et al. (2008) studied this question.
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