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The ability of thymus‐derived (T) cells activated by polymerized flagellin (POL) from Salmonella adelaide to transfer anti‐POL delayed‐type hypersensitivity (DTH) to normal mice was largely abrogated by pretreating the cells with anti‐Θ serum and complement, and completely abrogated by pretreating the cells with POL labelled with 125I‐iodine to hight specific activity. The thymocyte precursors of POL‐activated T cells were also inactivated by treatment with 125I‐POL. T cells activated by POL of one specificity were completely inactivated by 125I‐POL of the same or of anothei specificity but not at all by 125I‐labelIed haemocyanin (Jasus lalandii). Preincubation of POL‐activated T cells with rabbit anti‐mouse light chain globulin prevented their subsequent inactivation by 125I‐POL but did not reduce their ability to transfer anti‐POL DTH. The significance of these findings is discussed.
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Cooper et al. (1972) studied this question.
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