The Origin and Nature of the Methionine Residue Initiating the Synthesis of Haemoglobin in vivo and in vitro

This is the authors' abstract. We don't add key points for this paper.

The methionine residue which is transiently incorporated into the N‐terminal position during the initiation of both chains of rabbit globin, is provided solely by rabbit reticulocyte methionyl tRNAF and is not blocked or modified at any stage of the initiation process. This is true both for initiation observed in vitro and in vivo. All internal methionine residues of rabbit globin are provided by methionyl tRNAM.