Population
In vitro biochemical model studying caldesmon and smooth muscle myosin
Comparison
Ca2+/calmodulin-dependent phosphorylation of… vs Unphosphorylated caldesmon
Design
Preclinical
Authors
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Supports caldesmon phosphorylation as a latch-bridge mechanism in smooth muscle; leaves open its relevance to human vascular tone.
Phosphorylation of caldesmon blocks its interaction with smooth muscle myosin, providing a potential mechanism for reversible latch bridge formation in smooth muscle.
Sutherland et al. (1989) studied this question.
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