Population
Rat slow-twitch soleus, rat fast-twitch superficial vastus lateralis, and rabbit fast-twitch psoas skinned…
Comparison
Lowering pH to 6.20 at varying Ca2+… vs pH 7.00
Design
Preclinical
Authors
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Acidosis may impair submaximal force via slowed ktr in animal fibers; leaves open translation to human fatigue mechanisms.
Lowering pH depresses the rate constant of tension redevelopment at submaximal Ca2+ activation, which may partly explain reduced Ca2+ sensitivity and tension during muscle fatigue.
Metzger et al. (1990) studied this question.
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