Why the study?
Does mutation of highly conserved Gly468 or Glu470 in chicken smooth muscle myosin block the M x ATP --> M x ADP x Pi transition?
Does mutation of highly conserved Gly468 or Glu470 in chicken smooth muscle myosin block the M x ATP --> M x ADP x Pi transition?
Highly conserved Gly468 and Glu470 residues are essential for the M x ATP to M x ADP x Pi transition in the myosin active site.
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Gly468/Glu470 mutations disrupt myosin hydrolysis in avian smooth muscle; leaves open relevance to human cardiac myosin function.
Onishi et al. (1997) studied this question.
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