Key result
High-salt intake significantly increased left ventricular mass and fibrotic markers while down-regulating microRNA-133a expression in salt-sensitive rats compared to a low-salt diet.
Why the study?
Does high-salt intake suppress microRNA-133a expression and promote myocardial fibrosis in salt-sensitive rats?
Does high-salt intake suppress microRNA-133a expression and promote myocardial fibrosis in salt-sensitive rats?
High-salt intake down-regulates myocardial microRNA-133a expression, which may be a key mechanism driving myocardial fibrosis in salt-sensitive hypertension.
Salt-sensitive individuals show earlier and more serious cardiac damage than nonsalt-sensitive ones. Some studies have suggested that microRNA-133a could reduce cardiac hypertrophy and myocardial fibrosis. The current study aims to investigate the different functions of high-salt intake on salt-sensitive (SS) rats and Sprague-Dawley (SD) rats and the involvement of microRNA-133a in these roles. After high-salt intervention, the left ventricular mass (LVW) and left ventricular mass index (LVMI) of the salt-sensitive high salt (SHS) group were obviously higher than those of the salt-sensitive low salt (SLS) group. However, the difference between the Sprague-Dawley high salt (DHS) group and the Sprague-Dawley low salt (DLS) group was not significant. Compared with SLS group, collagen I and connective tissue growth factor (CTGF) in the heart of SHS group were significantly higher, whereas no statistical difference was observed between the DHS group and the DLS group. Compared with low-salt diet, microRNA-133a in the heart of both strains were significantly decreased, but that in the SHS group decreased more significantly. These results suggest that high salt intervention could down-regulate the expression of myocardial microRNA-133a, which may be one of the mechanisms involved in myocardial fibrosis in salt-sensitive hypertension.
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Guo et al. (2014) studied Salt-sensitive hypertension and myocardial fibrosis. High-salt intake vs. Low-salt diet was evaluated on Left ventricular mass, left ventricular mass index, collagen I, connective tissue growth factor, and microRNA-133a expression. High-salt intake significantly increased left ventricular mass and fibrotic markers while down-regulating microRNA-133a expression in salt-sensitive rats compared to a low-salt diet.
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