Key result
In individuals with spinal cord injury, upright arterial stiffness was elevated (+12%; p<0.05) and negatively correlated with reduced baroreflex sensitivity (R2=0.55; p<0.05).
Why the study?
Does arterial stiffening mediate baroreflex dysfunction after spinal cord injury, and does normalizing blood pressure with midodrine improve these parameters?
Observational
Does arterial stiffening mediate baroreflex dysfunction after spinal cord injury, and does normalizing blood pressure with midodrine improve these parameters?
p-value: p=<0.05
Reduced baroreflex sensitivity in spinal cord injury is closely related to increased arterial stiffness, which is not improved by normalizing blood pressure with midodrine.
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May link arterial stiffness to baroreflex impairment in spinal cord injury; hypothesis-generating and leaves open effects of blood pressure normalization.
Phillips et al. (2014) conducted an observational in High level spinal cord injury. High level spinal cord injury vs. Able-bodied controls was evaluated on Arterial stiffness (β-stiffness index) and spontaneous cardiovagal baroreflex sensitivity (BRS) (p=<0.05). In individuals with spinal cord injury, upright arterial stiffness was elevated (+12%; p<0.05) and negatively correlated with reduced baroreflex sensitivity (R2=0.55; p<0.05).
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