Key result
Circulating beta-endorphin levels were higher in diabetics with glomerular hyperfiltration than in those with normal GFR and controls, and positively correlated with GFR and renal plasma flow.
Observational
Circulating opioids like beta-endorphin may play a role in renal haemodynamic alterations in insulin-dependent diabetics.
Should not alter diabetic kidney disease management; hypothesis-generating for beta-endorphin in hyperfiltration.
Circulating opioids were studied in insulin-dependent diabetics with renal haemodynamic alterations. Higher circulating beta-endorphin (beta-EP) and lower beta-lipotropin (beta-LPH) levels were found in patients with glomerular hyperfiltration than in diabetics with normal glomerular filtration rate (GFR) and controls. Moreover, significantly positive correlations between beta-EP and GFR, and between beta-EP and renal plasma flow were demonstrated in these patients. On the contrary, reduced beta-EP levels were observed in diabetics with impaired GFR and overt nephropathy. Plasma renin activity was increased in diabetics with glomerular hyperfiltration and reduced in diabetics with overt nephropathy. Circulating opioids might, therefore, play a role in renal haemodynamic alterations, both in patients with early and advanced glomerular changes.
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Solerte et al. (2008) conducted an observational in Insulin-dependent diabetes with renal haemodynamic alterations. Glomerular hyperfiltration and impaired GFR vs. Diabetics with normal GFR and controls was evaluated on Circulating beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) levels, and plasma renin activity. Circulating beta-endorphin levels were higher in diabetics with glomerular hyperfiltration than in those with normal GFR and controls, and positively correlated with GFR and renal plasma flow.
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