Cerebrospinal Fluid in Tuberculous Meningitis

The cerebrospinal fluid in tuberculous meningitis has been studied since Quincke1introduced the method of lumbar puncture in 1891. Deniges and Sabrazes,2in 1896, compared the results of chemical analysis of the cerebrospinal fluid in 2 cases of tuberculous meningitis with the values in a case of rabies and suggested that further study would reveal a formula of the chemical changes in the cerebrospinal fluid characteristic of each infection of the central nervous system. Mestrezat and Gaujoux,3in 1909, reported findings in 2 cases of tuberculous meningitis confirming the formula of Deniges and Sabrazes.2Mestrezat,4in 1912, reported cerebrospinal fluid syndromes in a large number of diseases. With rare exceptions his observations have been confirmed. Mestrezat5further elaborated these cerebrospinal fluid syndromes on the basis of the physical and chemical characteristics of the fluid. In 1925, Fremont-Smith and Dailey6stated: It should again