Perfluoro‐n‐hexane in contrast to n‐hexane is not hydroxylated by the microsomal monooxygenation system in liver microsomes of phenobarbital treated rats. However, the fluorocarbon forms an enzyme‐substrate complex and, therefore, stimulates NADPH oxidation. Fluorocarbons can be regarded as dead‐end inhibitors which uncouple electron transport from monooxygenation. This effect must be taken into consideration when fluorocarbons are used as oxygen carriers in liver perfusion.
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Ullrich et al. (1971) studied this question.