Why the study?
Does anticoagulant use affect fetal and maternal outcomes in pregnant women with prosthetic heart valves?
Population
37 pregnant women with prosthetic heart valves.
Comparison
Anticoagulant therapy during pregnancy, mostly… vs No anticoagulant therapy during pregnancy…
Design
Cohort
Follow-up
Through pregnancy and neonatal period
Authors
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Anticoagulants were associated with worse fetal and maternal outcomes; leaves open optimal valve selection and peripartum strategies pending prospective data.
Does anticoagulant use affect fetal and maternal outcomes in pregnant women with prosthetic heart valves?
While women with artificial valves tolerate the hemodynamic load of pregnancy well, oral anticoagulants like warfarin are associated with increased fetal wastage and malformations, highlighting the advantages of biological valves in women of childbearing age.
Oakley et al. (1976) studied this question.
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