Key result
Cardiac troponin I and NT-proBNP are useful biomarkers in dogs and cats for differentiating cardiac from non-cardiac disease, detecting occult heart disease, and determining prognosis.
Cardiac biomarkers such as troponin I and NT-proBNP are useful in veterinary practice for diagnosing and prognosticating heart disease in dogs and cats, though appropriate interpretation is required.
May support biomarker use in veterinary cardiac evaluation; leaves open prospective validation for standardized thresholds.
Cardiac biomarkers can be helpful in differentiating cardiac from non-cardiac disease in dyspnoeic patients; in detecting occult heart disease; and in determining prognosis in patients with both cardiac and some non-cardiac diseases. Cardiac troponin I and N-terminal proB-type natriuretic peptide are the cardiac biomarkers most widely used in clinical practice and can easily be measured from a blood sample. However, there are limitations in their use, and appropriate interpretation of results is important. This article discusses the physiology of these biomarkers and the evidence available for their use in dogs and cats.
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Rachel Blake (2018) conducted a review in Cardiac and non-cardiac disease in dogs and cats. Cardiac biomarkers (cardiac troponin I and NT-proBNP) was evaluated. Cardiac troponin I and NT-proBNP are useful biomarkers in dogs and cats for differentiating cardiac from non-cardiac disease, detecting occult heart disease, and determining prognosis.
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