Key result
A 57-year-old female on warfarin developed acute kidney injury with a supratherapeutic INR, and renal biopsy revealed diffuse mesangial proliferative glomerulonephritis consistent with warfarin nephropathy.
Why the study?
Anticoagulant-related nephropathy is an underdiagnosed complication of anticoagulation associated with increased renal morbidity and all-cause mortality, emphasizing the need for regular kidney function monitoring and warfarin dose adjustment.
Case Report (n=1)
Warfarin-related nephropathy should be considered in patients on chronic warfarin therapy presenting with acute kidney injury and supratherapeutic INR.
Consider warfarin nephropathy in AKI with supratherapeutic INR; single case leaves open incidence and prevention data.
Warfarin is associated with anticoagulant-related nephropathy (ARN), one of the potential side effects. This is evidenced by a progressively increasing number of detected cases of deterioration in the kidney function even in patients with normal baseline function (GFR {glomerular filtration rate}) in addition to the chronic kidney disease (CKD) patients who are already vulnerable to ARN. There has been a clinical correlation in a rapid decline of kidney function and international normalized ratio (INR) levels of greater than three. ARN is a significant but underdiagnosed complication of anticoagulation that is associated with increased renal morbidity and all-cause mortality. We want to emphasize the importance of monitoring kidney function regularly and adjusting the appropriate doses of warfarin. We present a case of a 57-year-old female who was on warfarin for the mechanical aortic valve, presented with acute kidney injury and supratherapeutic INR. Her renal biopsy showed diffuse mesangial proliferative glomerulonephritis.
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Acquah et al. (2022) conducted a case report in Warfarin-related nephropathy (n=1). Warfarin was evaluated on Renal biopsy findings. A 57-year-old female on warfarin developed acute kidney injury with a supratherapeutic INR, and renal biopsy revealed diffuse mesangial proliferative glomerulonephritis consistent with warfarin nephropathy.
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