Key result
A woman in her 50s with a mechanical mitral valve replacement developed anticoagulant-related nephropathy due to supratherapeutic warfarin, which resolved upon temporary withdrawal of the drug.
Case Report (n=1)
This case highlights the need for high clinical suspicion of anticoagulant-related nephropathy in patients on warfarin presenting with acute kidney injury and supratherapeutic INR.
Supports suspicion for anticoagulant-related nephropathy in warfarin-associated AKI; single case report leaves open need for validation.
Anticoagulant-related nephropathy (ARN) is a rare type of acute kidney injury (AKI) caused by excessive anticoagulation with warfarin or other anticoagulants, such as direct oral anticoagulants (DOACs). We describe a case of a woman in her 50s with a background history of mitral valve replacement who was on warfarin and admitted for AKI, haematuria and a supratherapeutic international normalised ratio (INR) level. A renal biopsy showed red cell casts in the renal tubules, and a diagnosis of ARN was made. Her treatment included the temporary withdrawal of warfarin. Her renal function improved, and warfarin was restarted before she was discharged. This case highlights the importance of maintaining a high clinical suspicion when diagnosing ARN in patients who present with AKI and supratherapeutic INR levels.
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Then et al. (2025) conducted a case report in Anticoagulant-related nephropathy (n=1). Warfarin was evaluated on Anticoagulant-related nephropathy. A woman in her 50s with a mechanical mitral valve replacement developed anticoagulant-related nephropathy due to supratherapeutic warfarin, which resolved upon temporary withdrawal of the drug.
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