Key result
Warfarin-induced nephropathy triggers acute kidney injury, unmasking underlying IgA nephropathy in a case report.
Case Report (n=1)
Case report demonstrates acute kidney injury from anticoagulation-related nephropathy superimposed on IgA nephropathy, highlighting risks in patients with high international normalized ratio.
Anticoagulation-related nephropathy (ARN) is an uncommon diagnosis that should be considered in patients presenting with unexplained acute kidney injury (AKI) and coagulopathy. In this article, we present the case of a 70-year-old male with a history of cirrhosis and portal vein thrombosis on Coumadin who presented to the hospital with gross hematuria. The patient was diagnosed with AKI on chronic kidney disease (CKD) secondary to ARN superimposed on sclerosing IgA nephropathy. ARN, also known as warfarin-associated nephropathy, is an uncommon condition in which AKI from glomerular hemorrhage develops in a patient with an international normalized ratio greater than 3. The most common risk factor for development of ARN is CKD. AKI in our patient unearthed preexisting CKD due to IgA nephropathy as evidenced by the biopsy.
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Li et al. (2019) conducted a case report in Anticoagulation-related nephropathy (ARN) and acute kidney injury (n=1). Coumadin (warfarin) was evaluated on Anticoagulation-related nephropathy diagnosis. Coumadin exposure in a 70-year-old male led to anticoagulation-related nephropathy and acute kidney injury, unearthing preexisting chronic kidney disease due to IgA nephropathy.
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