Key result
Polymorphic variants of genes involved in the pathogenesis of atrial fibrillation are promising markers for predicting individual risk of developing the pathology.
Why the study?
AF frequency increases with age, reaching 50% in older groups, driving the need for individual AF risk markers to improve preventive efficacy.
Can molecular genetic markers predict the development of atrial fibrillation?
Can molecular genetic markers predict the development of atrial fibrillation?
Genetic markers, specifically polymorphic variants of genes involved in AF pathogenesis, hold promise as predictors for individual atrial fibrillation risk.
Answers are grounded in this paper and cite their sources.
Genetic markers may aid AF risk prediction; leaves open prospective validation before clinical use.
Atrial fibrillation (AF) is the supraventricular form of tachyarrhythmia characterized by uncoordinated atrial stimulation and manifested in the increased frequency of their contraction. The frequency of this pathology directly correlates with the patients’ age and reaches 50% in an older age group. This fact determines the need for search of any markers of individual AF risk, which may contribute to an increase in the effectiveness of preventive actions. Among such markers, polymorphic variants of genes involved in the pathogenesis of AF are the most promising markers. This review discusses the results of studying the genetic markers of the AF development, as well as the possibility of their use as predictors of this pathology.
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Понасенко et al. (2020) conducted a review in Atrial fibrillation. Molecular genetic markers was evaluated on Atrial fibrillation development. Polymorphic variants of genes involved in the pathogenesis of atrial fibrillation are promising markers for predicting individual risk of developing the pathology.
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