Genetic and molecular underpinnings of atrial fibrillation

Figures

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  Fig. 1. aCM and vCM-specific features. a Micrographs of isolated adult mouse ventricular and atrial cardiomyocytes. b Volcano plot obtained by pseudobulk RNA-seq analysis obtained from the human heart atlas. aCMs and vCMs were extracted from samples with >500 aCM or vCMs, pseudobulked, and compared using DEseq2. Genes with chamber selectivity were considered with Log2FC > |1| and pval adj. < 0.05. c Human and mouse data were plotted against each other to examine species-specific biases in chamber selectivity. The Pearson correlation coefficient (r = 0.4, p = 1.78E − 40) was determined for genes that were differentially expressed in both datasets. d Intersection between genes selectively expressed in human or mouse atria or ventricles.

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  Fig. 2. Characteristics of genes linked to atrial fibrillation. a Chamber-selective expression of atrial fibrillation genes. b Functional class of atrial fibrillation genes identified by GWAS. c Functional class of atrial fibrillation genes identified in pedigree and targeted sequencing studies.