Key result
A review of current genetic studies highlights efforts to delineate the fundamental mechanisms of atrial fibrillation, which may lead to more targeted and effective therapies.
This review highlights current efforts to delineate the fundamental genetic mechanisms of atrial fibrillation to develop targeted therapies.
Does not alter AF management; leaves open translation of genetic mechanisms to targeted therapies.
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Despite its prevalence, relatively little is known regarding the primary mechanisms of AF and, therefore, current treatment practices focus mainly on controlling the disorder and preventing its complications once it is already present. The study of the pathogenesis of AF is complicated by the varied clinical presentation of the arrhythmia and its coexistence with other cardiac pathologies. This article reviews current efforts to delineate the fundamental mechanisms of AF, with a focus on genetic studies. Identification of the underlying etiology may result in the development of more targeted and effective therapies for AF.
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Ellinor et al. (2006) conducted a review in Atrial fibrillation. Genetic studies was evaluated. A review of current genetic studies highlights efforts to delineate the fundamental mechanisms of atrial fibrillation, which may lead to more targeted and effective therapies.
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