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This paper reviews the potential contributions of genetic approaches to atrial fibrillation, noting the shift from studying rare monogenic mutations to complex polygenic predispositions.
This review highlights the evolving understanding of atrial fibrillation genetics, moving from rare monogenic mutations to complex polygenic predispositions and pharmacogenetics.
Does not yet support routine AF genetic testing; extends research toward polygenic risk and pharmacogenetics.
Atrial fibrillation (AF) is a consequence of a complex interplay of genetic, epigenetic and environmental factors. In addition, AF is a major contributor to stroke, heart failure, and mortality. Several family studies have shown a strong polygenetic predisposition for AF but, so far, most of the linkage analysis and candidate gene studies have discovered only monogenic, rare, deleterious mutations. While research in human genetics has moved from monogenic to oligogenic to complex diseases, its pharmacogenetics branch has followed, usually a few years behind. The present paper reviews the potential contributions of genetic approaches to AF.
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Ahmet Okay Çağlayan (2010) conducted a review in Atrial fibrillation. Genetic approaches was evaluated. This paper reviews the potential contributions of genetic approaches to atrial fibrillation, noting the shift from studying rare monogenic mutations to complex polygenic predispositions.
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