Bile induced chronic gastric ulcer in swine

The role of bile in the pathogenesis of chronic gastric ulcer was studied in 10 grown‐up miniature pigs. After an observation period of 14–186 days, 4 pigs out of 5 with total diversion of bile into the stomach developed peptic ulcers in the glandular part of the stomach, whereas none of 5 sham operated pigs developed ulcers after an observation period of 150–196 days. This difference was significant (p<0.05). In all 5 pigs with bile diversion the pyloric gland area enlarged at the cost of the fundic gland area, whereas this was not the case in the 5 controls. This difference was also significant (p<0.01). There was no significant change in gastric emptying after the operations. It is concluded that bile can cause gastric ulcer in the pig.