Busulfan in Pregnancy

THE TREATMENT of chronic granulocytic leukemia with busulfan (Myleran) (1,4-dimethanesulfonoxybutane ) in pregnancy is, apparently, uncommon. In reviewing the literature, only 2 reported cases were found in which busulfan alone had been used during pregnancy. This case is being reported to further substantiate the findings of Ixumi and Sherman that busulfan given during pregnancy has no apparent effect upon the fetus. Report of a Case A 29-year-old white female, when first seen in October, 1956, had had a history of known chronic granulocytic leukemia since lanuary, 1956, and had been given x-ray therapy. At this time, the spleen was down to the umbilicus and quite tender, and the white-blood-cell count was 232,000. Following a total of 150 r of whole-body irradiation, the spleen had become less tender and had regressed considerably in size. Concurrently, the white-blood-cell count gradually fell to about 75,000 and then started increasing. In August, 1956, she