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Human peripheral blood leukocyte granules contain a neutral esterase which hydrolyzes t-BOC-l-alanine p-nitrophenol, a synthetic substrate of elastase. The alanine p-nitrophenyl esterase was identified following isoelectric focusing of granule proteins in acrylamide gel and sucrose density-gradient systems. The enzyme proved highly basic, focusing at pH 9.4 in acrylamide gel and at pH 10.8 in the sucrose gradient.
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Janoff et al. (1971) studied this question.
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