Ciprofloxacin and Warfarin

Letters and Corrections15 September 1989Ciprofloxacin and WarfarinFrank E. Mott, MD, Sean Murphy, MD, Vernon Hunt, MDFrank E. Mott, MD, Sean Murphy, MD, Vernon Hunt, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-542_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recent letter by Linville and Matanin (1) brought attention to an interaction between norfloxacin (Noroxin, Merck Sharp & Dohme, West Point, Pennsylvania) and warfarin that resulted in an increased prothrombin time. We would like to report a case of a similar interaction between warfarin and ciprofloxacin (Cipro, Miles Inc., West Haven, Connecticut), another of the fluoroquinolone antibiotics.A 72-year-old white man with end-stage cardiomyopathy and a prosthetic aortic valve who was receiving chronic warfarin therapy was hospitalized with worsening congestive heart failure. He also had gout, type II diabetes mellitus, hypertension, chronic renal insufficiency, and hypothyroidism. In addition to...References1. LinvilleMatanin TD. Norfloxacin and warfarin. Ann Intern Med. 1989;110:751. LinkGoogle Scholar2. SellerKoch-Weser EJ. Displacement of warfarin from human albumin by diazoxide and thacrynic, wefenamic, and nalidixic acids. Clin Pharmacol Ther. 1970;11:524-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Wisconsin Madison, WI 53792 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuinolonesManagement of the Elderly Patients with Inflammatory Bowel DiseaseQuinolonesInteractions Between Warfarin and Three Commonly Prescribed FluoroquinolonesCiprofloxacin Prolonged-Release Tablets Do Not Affect Warfarin Pharmacokinetics and PharmacodynamicsThe safety of levofloxacin in elderly patients on warfarinMoxifloxacin and Warfarin: Additional Evidence for a Clinically Relevant InteractionIncreasing Warfarin Dosage Reductions Associated with Concurrent Warfarin and Repeated Cycles of 5-Fluorouracil TherapyAbnormal coagulation studies associated with levoflaxacinThe interaction of moxifloxacin and warfarin in three elderly patientsAdverse Drug Reactions Related to the Use of Fluoroquinolone AntimicrobialsLevofloxacin and Warfarin InteractionINTERACTIONS OF WARFARINLevofloxacin and Warfarin InteractionPharmacokinetic Aspects of Treating Infections in the Intensive Care UnitCiprofloxacin-warfarin coagulopathy: A case seriesClinical PharmacologyDrug Interactions with Antimicrobial AgentsAbsence of an Effect of Levofloxacin on Warfarin Pharmacokinetics and Anticoagulation in Male VolunteersEffect of ciprofloxacin on the hypoprothrombinemic activity of warfarin in ratsUrinary Tract InfectionsDrug interactions with fluoroquinolonesOverview of fluoroquinolone safetyCiprofloxacin-Warfarin InteractionCiprofloxacin interaction with sodium warfarin: A potentially dangerous side effectCiprofloxacin and warfarin interactionCiprofloxacin and warfarin interactionPossible Interaction between Ciprofloxacin and Warfarin 15 September 1989Volume 111, Issue 6Page: 542-543KeywordsAntibioticsAortic valveCardiomyopathiesDiabetes mellitusGoutHeart failureHypertensionHypothyroidismProthrombin time Issue Published: 15 September 1989 PDF downloadLoading ...