Nicoumalone and Nalidixic Acid Interaction

Letters1 April 1980Nicoumalone and Nalidixic Acid InteractionISRAEL POTASMAN, M.D., HARRY BASSAN, M.D.ISRAEL POTASMAN, M.D., HARRY BASSAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-571_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A 65-year-old woman suffering from hypothyroidism and ischemic heart disease was admitted with hemoptysis and breathlessness found to be due to pulmonary embolism. Treatment was commenced with heparin and nicoumalone (a warfarin derivative). Within the first 4 days she received a total of 32 mg of nicoumalone, and satisfactory levels of prothrombin time were achieved. On the fifth day the prothrombin time was 26 s (control, 9.7 s). On the following day, proven urinary tract infection necessitated the administration of nalidixic acid. The drug was given in a daily dose of 1 g.Quite unexpectedly a further...References1. HOFFBRAND B. Interaction of nalidixic acid and warfarin. Br Med J. 1974;2:666. Letter. CrossrefMedlineGoogle Scholar2. SELLERS E and KOCH-WESER J. Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefenamic, and nalidixic acids. Clin Pharmacol Ther. 1970;11:524-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ISRAEL POTASMAN, M.D.; HARRY BASSAN, M.D.Affiliations: Department of Internal Medicine B Rothschild University Hospital Haifa, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byINTERACTIONS OF WARFARINInteraction Between Nalidixic Acid and WarfarinJONATHAN LEOR, M.D., DAVID LEVARTOWSKY, M.D., CHARLOTTE SHARON, M.D.Absence of interaction between ofloxacin and phenprocoumonAntimicrobials and Haemostasis 1 April 1980Volume 92, Issue 4Page: 571-571KeywordsCardiovascular therapyDrugsDyspneaHeparinHypothyroidismProthrombin timePulmonary embolism ePublished: 1 December 2008 Issue Published: 1 April 1980 PDF downloadLoading ...