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Operationally simple condensation of dl -alanine amino acid with substituted aromatic aldehydes/heterocyclic aldehyde occurs to afford Schiff bases in quantitative yield under organic solvent-free conditions efficiently in the presence of water as a green solvent. The operational simplicity, environmentally friendly conditions and high yield achieved are major benefits that meet the requirements of green production, including saving energy and high efficiency. Structural assignments are based on spectroscopic data. The compounds have also been screened for antibacterial and antifungal activities and most of the Schiff bases have shown potent antibacterial and antifungal activity.
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Sachdeva et al. (2012) studied this question.
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